FWIW, TOSNA was updated a few months ago on the MMR site now using more realistic YAN requirement levels, even further tailored by yeast strain.
I have been using the TOSNA 2.0 close to a year now at the meadery with great success. Before, our fermentations where ripping along at high activity even at 14% abv mark. We would need to cold crash our tanks to halt it.
TOSNA 2.0 has shown immediately noticeable results to the effect that our fermentations are now coming to a nice slow and steady finish. I believe the dosage rates are now pretty dialed in to the point to more realistic addition rates based on more precise numbers.
Also, STASIS, great find on the research pertaining to proline and the theory as to how it might be the underlining reason with how Fermaid-O works so well while (technically on paper) it underfeeds the yeast. Super interesting that I will most certainly be spending a good amount of time starting to look into.
I wish I had more time to log in and be more active here in GM to have been more a part of the overall conversation, but this has been one of the best threads I've seen in years here.
I, in no way shape or form, fall into the (respectively) "bio-nerd" classification, but you all who are and have shared the workings behind the scenes of what is really going on here is amazing. Kudos to you all.
As a final note, if there is a specific experimentation you could collaborate with deciding on that you would like me to conduct, please do let me know.
Thanks for stopping by. I joined the AMMA hoping to find this sort of discussions. I wish more of you top shelf pro's could spend more time with us over hear. I think this is the best forum for sure for all things a mazing LOL
Please let us know what you find in regards to proline.